Phone: +86 (0) 592-2184520
E-mail: zh@xmu.edu.cn
Address:
Lu Jiaxi Building 742
Department of Chemistry,
College of Chemistry and Chemical Engineering,
Xiamen University, Xiamen 361005, China
Education:
BS (1997-2001), Material Science,College of Chemistry and Chemical Engineering, Xiamen University
PhD (2001-2007), Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University
Research Experience:
Research Associate (2012-2013), Computational Chemistry, Department of Chemistry,The Hong Kong University of Science & Technology, Hong Kong (Prof. Zhenyang Lin)
Visiting Professor (2019-2020), Organic Chemistry, Department of Chemistry and Biochemistry, University of California, Los Angeles, United States (Prof. Kendall N. Houk)
Honors and Awards:
The State Natural Science Award (the Second Prize, 2020, the Second Accomplisher)
Thieme Chemistry Journals Award (2019)
The Top-Notch Young Talents Program of Fujian Province (2020)
Natural Science Award of Fujian Province (the First Prize, 2018, the Second Accomplisher)
Program for New Century Excellent Talents in Fujian Province University (2018)
Teaching Contest for University Young Teachers of Fujian Province (the First Prize, 2014)
Principal Research Interests:
Organometallic Chemistry: 1. Strained Metallacycles with Main Group Elements; 2. Extending Classical Organic Reactions to Organometallic Chemistry; 3. Novel Methodology for Organic Synthesis via Metal Carbene or Metal Carbyne
Selected Recent Publications:
Lin, Z.;† Cai, Y.;† Zhang, Y.; Zhang, H.;* Xia, H.* Heterocyclic Suzuki–Miyaura coupling reaction of metalla-aromatics and mechanistic analysis of site selectivity. Chem. Sci. 2023,14, 1227-1233.
Cai, Y.; † Hua, Y.; † Lu, Z.; Lan, Q.; Lin, Z.; Fei, J.; Chen, Z.; Zhang, H.;* Xia, H.* Electrophilic aromatic substitution reactions of compounds with Craig-Mobius aromaticity. Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2102310118.
Zhang, H.;* Thogersen, M. K.; Jamieson, C. S.; Xue, X.-S.; Jorgensen, K. A.;* Houk, K. N.* Ambimodal Transition States in Diels-Alder Cycloadditions of Tropolone and Tropolonate with N-Methylmaleimide. Angew. Chem. Int. Ed. 2021, 60, 24991–24996.
Zhang, H.;* Novak, A. J. E.; Jamieson, C. S.; Xue, X. S.; Chen, S.; Trauner, D.;* Houk, K. N.* Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions. J. Am. Chem. Soc. 2021, 143, 6601-6608.
Lu, Z.; † Zhu, Q.; † Cai, Y.; Chen, Z.; Zhuo, K.; Zhu, J.; Zhang, H.;* Xia, H.* Access to Tetracyclic Aromatics with Bridgehead Metals via Metalla-click Reactions. Sci. Adv. 2020, 6, eaay2535.
Huang, F.; Zheng, X.; Lin, X.; Ding, L.; Zhuo, Q.; Wen, T. B.; Zhang, H.;* Xia, H.* Extension of the Simmons–Smith Reaction to Metal-carbynes: Efficient Synthesis of Metallacyclopropenes with σ-Aromaticity. Chem. Sci. 2020, 11, 10159-10166.
Zhou, X.; Pang, X.; Nie, L.; Zhu, C.; Zhuo, K.; Zhuo, Q.; Chen, Z.; Liu, G.; Zhang, H.;* Lin, Z.; Xia, H. Successive Modification of Polydentate Complexes Gives Access to Planar Carbon- and Nitrogen-based Ligands. Nat. Commun. 2019, 10, 1488.
Zhou, X.; Zhang, H.* Reactions of Metal–Carbon Bonds within Six-Membered Metallaaromatic Rings. Chem. - Eur. J. 2018, 24, 8962-8973. (mini review)
Hua, Y.; Zhang, H.;* Xia, H.* Aromaticity: History and Development. Chin. J. Org. Chem. 2018, 38, 11-28. (review)
Luo, M.; Long, L.; Zhang, H.;* Yang, Y.; Hua, Y.; Liu, G.; Lin, Z.;* Xia, H.* Reactions of Isocyanides with Metal Carbyne Complexes: Isolation and Characterization of Metallacyclopropenimine Intermediates. J. Am. Chem. Soc. 2017, 139, 1822-1825.
