Education and Research Experience: 

BS (2007),  Xiamen University
PhD (2012),  Xiamen University
Postdoctoral fellow (2019),  University of Alberta
Associate professor (2020),  Xiamen University

Principal Research Interests:
Functional elemental tags for quantification and identification of biomolecules, arsenic-thiol/protein interaction, Arsenical drugs, targeted drug delivery and controlled release

Selected Recent Publications:

1. Xiaowen Yan, X. Chris Le.* Fluorescence imaging of Cu(I) in endoplasmic reticulum of live cells and tissue. Sci. China Chem. 2019, 62, 887-888.

2. Xiaowen Yan, X. Chris Le,* Hongquan Zhang.* Antibody-bridged beacon for homogeneous detection of small molecules. Anal. Chem. 2018, 90, 9667–9672.

3. Xiaowen Yan, Hongquan Zhang,* Zhixin Wang, Hanyong Peng, Jeffrey Tao, Xing-Fang Li, X. Chris Le.* Quantitative synthesis of protein-DNA conjugates with 1:1 stoichiometry. Chem. Commun. 2018, 54, 7491–7494.

4. Xiaowen Yan, Jinhua Li, Qingqing Liu, Hanyong Peng, Aleksandra Popowich, Zhixin Wang, Xing-Fang Li, X. Chris Le.* p-Azidophenylarsenoxide: An arsenical "bait" for the in-situ capture and identification of cellular arsenic-binding proteins. Angew. Chem. Int. Ed. 2016, 55, 14051–14056.

5. Xiaowen Yan, Zhaoxin Li, Yong Liang, Limin Yang, Bo Zhang, Qiuquan Wang.* A chemical “hub” for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry. Chem. Commun. 2014, 50, 6578–6581.

6. Xiaowen Yan, Limin Yang, Qiuquan Wang.* Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges. Anal. Bioanal. Chem. 2013, 405, 5663–5670.

7. Xiaowen Yan, Yacui Luo, Zhubao Zhang, Zhaoxin Li, Qiang Luo, Limin Yang, Bo Zhang, Haifeng Chen, Peiming Bai, Qiuquan Wang.* Europium-labeled activity-based probe through click chemistry: absolute serine protease quantification using ¹⁵³Eu isotope dilution ICP/MS. Angew. Chem. Int. Ed. 2012, 51, 3358–3363.

8. Xiaowen Yan, Limin Yang, Qiuquan Wang.* Lanthanide-coded protease-specific peptide–nanoparticle probes for label-free multiplex protease assay using element mass spectrometry: a proof-of-concept study. Angew. Chem. Int. Ed. 2011, 50, 5130–5133.

9. Xiaowen Yan, Ming Xu, Limin Yang, Qiuquan Wang.* Absolute quantification of intact proteins via 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimido-ethylacetamide-europium labeling and HPLC coupled with species-unspecific isotope dilution ICPMS. Anal. Chem. 2010, 82, 1261–1269.