E-mail: thy@xmu.edu.cn
Address:
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Education and Research Experience:
B.S. (1994-1998), Polymer Materials, School of Science, Harbin Institute of Technology
M.S. (1998-2000), Materials, School of Science, Harbin Institute of Technology
Ph.D. (2002-2005), Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
SELECTED HONORS AND AWARDS
Tian Huayu is one of the “Nan Qiang Distinguished Professors” at Xiamen University who has been awarded “Recipient of the National Outstanding Youth Fund Professor”. Prof. Tian has published more than 170 articles in international mainstream journals such as Journal of the American Chemical Society, Angewandte Chemie International Edition, Nature Communications, Science Advances, Advanced Materials, Advanced Functional Materials, ACS Nano, Nano Letters, etc. He has obtained over 30 Chinese invention patents.
He also served as visiting research of Korea Advanced Institute of Science and Technology (KAIST) in 2007 and Kyushu University in 2008.
Dr. Tian has received 7 major awards:
The first prize of Jilin Province Science and Technology Progress Award (ranked third), 2007
The first prize of Jilin Province Science and Technology Progress Award (ranked third), 2010
The "Chinese Chemical Society Polymer Science Innovation Paper Award", 2015
The Outstanding Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences, 2016
The Jilin Province Natural Science Academic Achievement Award, 2017
The Jilin Province Patent Excellence Award, 2019
The first prize of Jilin Province Natural Science Award (ranked first), 2021
Principal Research Interests:
Biomedical polymers; Nano-gene/drug carriers; Biotherapy, Nucleic acid vaccines; Immunotherapy; Energy polymers
Selected Recent Publications:
1. Fang H, Guo Z, Chen J, Lin L, Hu Y, Li Y*, Tian H*, Chen X. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Nature Communications, 2021, 12:6742.
2. Liu F, Sheng S, Shao D, Xiao Y, Zhong Y, Zhou J, Quek C H, Wang Y, Dawulieti J, Yang C, Tian H*, Chen X, Leong K W*. Targeting multiple mediators of sepsis using multifunctional tannic acid-Zn2+-gentamicin nanoparticles. Matter, 2021, 1-19.
3. Wang Y, Xu C, Meng M, Lin L, Hu Y, Hao K, Sheng S, Zhang S, Wu J, Liu F, Jiang X*, Tian H*, Chen X. Precise regulation of inflammation and immunosuppressive microenvironment for amplified photothermal/immunotherapy against tumour recurrence and metastasis. Nano Today, 2021, 40:101266.
4. Feng Y, Wu J, Chen J, Lin L, Zhang S, Yang Z, Sun P, Li Y*, Tian H*, Chen X. Targeting dual gene delivery nanoparticles overcomes immune checkpoint blockade induced adaptive resistance and regulates tumor microenvironment for improved tumor immunotherapy. Nano Today, 2021, 38:101194.
5. Ni W, Wu J, Fang H, Feng Y, Hu Y, Lin L, Chen J*, Chen F*, Tian H*. Photothermal-Chemotherapy Enhancing Tumor Immunotherapy by Multifunctional Metal–Organic Framework Based Drug Delivery System. Nano Letters, 2021, 7796-7805.
6. Xu C, Wang Y, Wang E, Yan N, Sheng S, Chen J, Lin L, Guo Z, Tian H*, Chen X. Effective Eradication of Tumors by Enhancing Photoacoustic-Imaging-Guided Combined Photothermal Therapy and Ultrasonic Therapy. Advanced Functional Materials, 2021, 31:2009314.
7. Liu F, Sheng S, Shao D, Xiao Y, Zhong Y, Zhou J, Quek C H, Wang Y, Hu Z, Liu H, Li Y*, Tian H*, Leong K W*, Chen X. A Cationic Metal-Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management. Nano Letters, 2021, 21:2461-2469.
8. Hao K, Lin L, Sun P, Hu Y, Atsushi M, Guo Z*, Tian H*, Chen X. Cationic Flexible Organic Framework for Combination of Photodynamic Therapy and Genetic Immunotherapy Against Tumors. Small, 2021, 17:2008125.
9. Wu J, Chen J, Feng Y, Zhang S, Lin L, Guo Z, Sun P, Xu C, Tian H*, Chen X. An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles. Science Advances, 2020, 6:eabc7828.
10. Liu, F.; Lin, L.; Zhang, Y.; Wang, Y.; Sheng, S.; Xu, C.; Tian H*; Chen, X*, A Tumor-Microenvironment-Activated Nanozyme-Mediated Theranostic Nanoreactor for Imaging-Guided Combined Tumor Therapy, Advanced Materials, 2019, 31, 1902885.
11. Liu, F; Lin, L; Zhang, Y; Sheng, S; Wang, Y; Xu, C; Tian H*; Chen, X, Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy, Biomaterials, 2019, 223, 119470.
12. Wang, D.; Zhang, Z.; Lin, L.; Liu, F.; Wang, Y.; Guo, Z.; Li, Y.; Tian H*, Chen, X., Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy, Biomaterials, 2019, 223, 119459.
13. Hu Y Y, Lin L, Chen J*, Maruyama A, Tian H*, Chen X. Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger. Biomaterials, 2020, 252:13.
14. Zhang, Y.; Lin, L.; Liu, L.; Liu, F.; Sheng, S.; Tian H*; Chen, X., Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy. Biomaterials, 2019, 216, 119255.
15. Yan N, Lin L, Xu C*, Tian H*, Chen X. A GSH-Gated DNA Nanodevice for Tumor-Specific Signal Amplification of microRNA and MR Imaging-Guided Theranostics. Small, 2019, 15, 1903016.
16. Fang, H.; Guo, Z.; Lin, L.; Chen, J.; Sun, P.; Wu, J.; Xu, C.; Tian H.*; Chen, X.*, Molecular strings significantly improved the gene transfection efficiency of polycations. Journal of the American Chemical Society 2018, 140 (38), 11992-12000.
17. Zhen, W.; Liu, Y.; Lin, L.; Bai, J.; Jia, X.; Tian H.*; Jiang, X.*, BSA-IrO2: catalase-like nanoparticles with high photothermal conversion efficiency and a high X-ray absorption coefficient for anti-inflammation and antitumor theranostics. Angewandte Chemie International Edition 2018, 57 (32), 10309-10313.
18. Xu, C.; Wang, Y.; Yu, H.; Tian H.*; Chen, X.*, Multifunctional theranostic nanoparticles derived from fruit-extracted anthocyanins with dynamic disassembly and elimination abilities. ACS Nano, 2018, 12 (8), 8255-8265.
19. Yan, N.; Wang, X.; Lin, L.; Song, T.; Sun, P.; Tian H.*; Liang, H.*; Chen, X.*, Gold nanorods electrostatically binding nucleic acid probe for in vivo microRNA amplified detection and photoacoustic imaging-guided photothermal therapy. Advanced Functional Materials, 2018, 28 (22), 1800490.
20. Guan, X.; Guo, Z.; Lin, L.; Chen, J.; Tian, H.*; Chen, X.*, Ultrasensitive pH triggered charge/size dual-rebound gene delivery system. Nano Letters, 2016, 16 (11), 6823-6831.
