题 目：Progress on Nitrogenase Mechanism
固氮酶机理研究进展
讲座人：倪锋 博士
University of Southern California
时 间：2014年12月23日（星期二）09:00
地 点：卢嘉锡楼202报告厅
欢迎参加！
化学生物学福建省重点实验室
2014年12月17日
Feng Ni
Department of Chemistry
University of Southern California, LA, CA, 90089
Education and Research Experience
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1999.9-2003.7 |
B.S. in Chemistry, Xiamen University (Xiamen, China) Undergraduate thesis guided by Professor Yu-Fen Zhao
“Synthesis of N-diisopropyloxyphosphoryl dipeptides”
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2006.9-2007.1 |
Visitor, Institute of Biological Structure, CNRS (Grenoble, France) Collaborative Research with Professor Martin J. Field
“QM/MM calculation of Nε-phospholysine intermediate in protein kinase” |
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2003.9-2009.5
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Ph.D. in Organic Chemistry, Xiamen University (Xiamen, China) Graduate Research instructed by Professor Yu-Fen Zhao
“Synthesis and reactivity of N-phosphono-amino acids (NPAAs)
----model compounds study of P-N bond in life chemistry”
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2009.8-2014.6
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Postdoctoral fellow/Research Associate, University of Southern California (Los Angeles, USA) Research with Professor Charles E. McKenna
“Synthesis of chemical probe and study of the mechanism of nitrogenase; Synthesis, design and biological studies of novel enzyme inhibitors”
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2014.7-present |
Research Associate, University of Southern California (Los Angeles, USA) Research with Professor Charles E. McKenna
Design and Synthesis of artificial nitrogenase for nitrogen fixation |
Publications
1. Ni, F.; Lee, C. C.; Hwang, S. W.; Hu, Y.; Ribbe, W. M.; McKenna, C. E. Reduction of Fluorinated Cyclopropene by Nitrogenase. The Journal of American Chemical Society, 2013, 135, 10346-10352
2. Błażewska, K. M.; Ni, F.; Haiges, R.; Kashemirov, B. A.; Coxon, F. P.; Stewart, R. B.; Baron, R.; Rogers, M. J.; Seabra, M. C.; Ebetino, F. H.; McKenna, C. E. Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. European Journal of Medicinal Chemistry, 2011, 46, 4820-4826
3. Xiang, G., Ni, F., Bao, J., Liu, Y., Zhang, Z., Xu, P. X., Zhao, Y. F. Formation of cyclic acylphosphoramidates in mass spectra of N-monoalkyloxyphosphoryl amino acids using electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry, 2010, 45(7), 779–787.
4. Liu, X.X.; Zhang, J.X.; Ni, F.; Dong, X.; Han, B.C.; Han, D.X.; Ji, Z.L.; Zhao, Y.F. Genome wide exploration of the origin and evolution of amino acids. BMC Evolutionary Biology. 2010, 10, 77
5. Ni, F.; Sun, S. T.; Huang, C.; Zhao, Y. F. N-phosphorylation of Amino acids by Trimetaphosphate in Aqueous SolutioN---Learning from Prebiotic Synthesis Green Chemistry, 2009, 11, 569-573.
6. Ni, F.; Gao, X.; Zhao, Z. X.; Huang, C,; Zhao, Y. F. On the Electrophilicity of Cyclic Acylphosphoramidates Postulated as Intermediates, European Journal of Organic chemistry, 2009,18.3026-3035.
7. Ni, F.; Li, W.; Li, Y. M.; Zhao, Y. F. Analysis of the phosphoryl transfer mechanism of c-AMP dependent protein kinase (PKA) by penta-coodinate phosphoric transition state theory Current Protein and Peptide Science, 2005, 6, 437-442
8. Tang, G, Zhou, G. J, Ni, F. Zhao, Y. F. P-31 NMR and ESI-MS studies on some intermediates of the peptide coupling reagents triphenyl-chlorophosphoranes. Chinese Chemical Letter 2005, 16, 385-388.
Conference Abstract and Presentations
(A=abstract, P=poster, O=Oral)
O-1, Ni, F.; Zhao, Y. F. Interpretation of reactivity for N-dialkyloxyphosphoryl amino acids by theoretical calculations. 7th National Conference on Phosphorus Chemistry, Zhengzhou, China, 2006, April
A-1, Ni, F.; Sun, S. T.; Zhao, Y. F. Inter/intra-molecular phosphoryl transfer reactions of N-phosphoryl amino acids. 5th National Conference on Chemical Biology, Yunnan, China, 2007, August
A-2, Ni, F.; Zhao, Y. F. 31P-NMR investigation on N-phosphoryl amino acids a Kinase model analysis. 14th National Meeting on Spectrometry, Xi’an, China, 2006, October
P-1, Ni, F.; Fu, C.; Sun S. T.; Zhao, Y. F. Green synthesis of N-phosphono-amino acids by trimetaphosphate (P3m) 17th International Conference on Phosphorus Chemistry, Xiamen, China, 2007, April
A-3, Ni, F.; Zeng, Z. P.; Zhao, Y. F. Locating the reaction paths of N-(dialkyloxyphosphoryl) amino acids by nudged elastic band (NEB) method. 17th International Conference on Phosphorus Chemistry, Xiamen, China, 2007, April
O-2, Ni, F.; Kung, A.; Zhang C.; McKenna, C. E. Synthesis of α,β-CXY-NTP (X≠Y: H, F, Cl; N=Nucleoside) diastereomers and their activities as protein kinase substrates. 245th ACS meeting, New Orleans, 2013, April
P-2, Ni, F.; Lee, C. C.; Hwang, S. W.; Hu, Y.; Ribbe, W. M.; McKenna, C. E. Reduction of Fluorinated Cyclopropene by Nitrogenase. 245th ACS meeting, New Orleans, 2013, April
Patent
Zhao, Y. F.; Zhao, Z. X.; Ni, F. A convenient synthesis of phosphoramidates and pyrophosphoramdiates, 200910111809.0
