田华雨

教育简历：

1994-1998，哈尔滨工业大学，高分子材料专业，本科

1998-2000，哈尔滨工业大学，高分子材料专业，硕士

2002-2005，中国科学院长春应用化学研究所，高分子化学专业，博士

工作经历：

2006-2008，中国科学院长春应用化学研究所，助理研究员

2007.6-7，韩国科学技术院（KAIST），客座研究

2008.8，日本九州大学，客座研究

2008-2012，中国科学院长春应用化学研究所，副研究员

2009-2010，美国犹他大学，访问学者

2012-2022，中国科学院长春应用化学研究所，研究员

2022-现在，澳门沙金在线平台，教授

主要奖励：

2007年，获吉林省科学技术进步一等奖（排名第三）

2011年，获吉林省科学技术进步一等奖（排名第三）

2015年，获“中国化学会高分子科学创新论文奖”

2016年，获中国科学院2016年度青年创新促进会优秀会员

2018年，获吉林省自然科学学术成果奖

2019年，获吉林省专利优秀奖

2021年，获吉林省自然科学一等奖（排名第一）

研究兴趣：

生物医用高分子、纳米基因/药物载体、生物治疗、核酸疫苗、免疫治疗、能源高分子

近期主要代表论著：

1. 1. Fang H, Guo Z, Chen J, Lin L, Hu Y, Li Y*, Tian H*, Chen X. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Nature Communications, 2021, 12:6742.

2. 2. Liu F, Sheng S, Shao D, Xiao Y, Zhong Y, Zhou J, Quek C H, Wang Y, Dawulieti J, Yang C, Tian H*, Chen X, Leong K W*. Targeting multiple mediators of sepsis using multifunctional tannic acid-Zn2+-gentamicin nanoparticles. Matter, 2021, 1-19.

3. 3. Wang Y, Xu C, Meng M, Lin L, Hu Y, Hao K, Sheng S, Zhang S, Wu J, Liu F, Jiang X*, Tian H*, Chen X. Precise regulation of inflammation and immunosuppressive microenvironment for amplified photothermal/immunotherapy against tumour recurrence and metastasis. Nano Today, 2021, 40:101266.

4. 4. Feng Y, Wu J, Chen J, Lin L, Zhang S, Yang Z, Sun P, Li Y*, Tian H*, Chen X. Targeting dual gene delivery nanoparticles overcomes immune checkpoint blockade induced adaptive resistance and regulates tumor microenvironment for improved tumor immunotherapy. Nano Today 2021, 38:101194.

5. 5. Ni W, Wu J, Fang H, Feng Y, Hu Y, Lin L, Chen J*, Chen F*, Tian H*. Photothermal-Chemotherapy Enhancing Tumor Immunotherapy by Multifunctional Metal–Organic Framework Based Drug Delivery System. Nano Letters, 2021, 7796-7805.

6. 6. Xu C, Wang Y, Wang E, Yan N, Sheng S, Chen J, Lin L, Guo Z, Tian H*, Chen X. Effective Eradication of Tumors by Enhancing Photoacoustic-Imaging-Guided Combined Photothermal Therapy and Ultrasonic Therapy. Adv Funct Mater, 2021, 31:2009314.

7. 7. Liu F, Sheng S, Shao D, Xiao Y, Zhong Y, Zhou J, Quek C H, Wang Y, Hu Z, Liu H, Li Y*, Tian H*, Leong K W*, Chen X. A Cationic Metal-Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management. Nano Letters, 2021, 21:2461-2469.

8. 8. Hao K, Lin L, Sun P, Hu Y, Atsushi M, Guo Z*, Tian H*, Chen X. Cationic Flexible Organic Framework for Combination of Photodynamic Therapy and Genetic Immunotherapy Against Tumors. Small, 2021, 17:2008125.

9. 9. Wu J, Chen J, Feng Y, Zhang S, Lin L, Guo Z, Sun P, Xu C, Tian H*, Chen X. An immune cocktail therapy to realize multiple boosting of the cancer-immunity cycle by combination of drug/gene delivery nanoparticles. Science Advances, 2020, 6:eabc7828.

10. 10. Liu, F.; Lin, L.; Zhang, Y.; Wang, Y.; Sheng, S.; Xu, C.; Tian H*; Chen, X*, A Tumor-Microenvironment-Activated Nanozyme-Mediated Theranostic Nanoreactor for Imaging-Guided Combined Tumor Therapy, Advanced Materials, 2019, 31, 1902885.

11. 11. Liu, F; Lin, L; Zhang, Y; Sheng, S; Wang, Y; Xu, C; Tian H*; Chen, X, Two-dimensional nanosheets with high curcumin loading content for multimodal imaging-guided combined chemo-photothermal therapy, Biomaterials, 2019, 223, 119470.

12. 12. Wang, D.; Zhang, Z.; Lin, L.; Liu, F.; Wang, Y.; Guo, Z.; Li, Y.; Tian H*, Chen, X., Porphyrin-based covalent organic framework nanoparticles for photoacoustic imaging-guided photodynamic and photothermal combination cancer therapy, Biomaterials, 2019, 223, 119459.

13. 13. Hu Y Y, Lin L, Chen J*, Maruyama A, Tian H*, Chen X. Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger. Biomaterials, 2020, 252:13.

14. 14. Zhang, Y.; Lin, L.; Liu, L.; Liu, F.; Sheng, S.; Tian H*; Chen, X., Positive feedback nanoamplifier responded to tumor microenvironments for self-enhanced tumor imaging and therapy. Biomaterials 2019, 216, 119255.

15. 15. Yan N, Lin L, Xu C*, Tian H*, Chen X. A GSH-Gated DNA Nanodevice for Tumor-Specific Signal Amplification of microRNA and MR Imaging-Guided Theranostics. Small, 2019, 15, 1903016.

16. 16. Fang, H.; Guo, Z.; Lin, L.; Chen, J.; Sun, P.; Wu, J.; Xu, C.; Tian H.*; Chen, X.*, Molecular strings significantly improved the gene transfection efficiency of polycations. Journal of the American Chemical Society 2018, 140 (38), 11992-12000.

17. 17. Zhen, W.; Liu, Y.; Lin, L.; Bai, J.; Jia, X.; Tian H.*; Jiang, X.*, BSA-IrO2: catalase-like nanoparticles with high photothermal conversion efficiency and a high X-ray absorption coefficient for anti-inflammation and antitumor theranostics. Angewandte Chemie International Edition 2018, 57 (32), 10309-10313.

18. 18. Xu, C.; Wang, Y.; Yu, H.; Tian H.*; Chen, X.*, Multifunctional theranostic nanoparticles derived from fruit-extracted anthocyanins with dynamic disassembly and elimination abilities. ACS Nano 2018, 12 (8), 8255-8265.

19. 19. Yan, N.; Wang, X.; Lin, L.; Song, T.; Sun, P.; Tian H.*; Liang, H.*; Chen, X.*, Gold nanorods electrostatically binding nucleic acid probe for in vivo microRNA amplified detection and photoacoustic imaging-guided photothermal therapy. Advanced Functional Materials 2018, 28 (22), 1800490.

20. 20. Guan, X.; Guo, Z.; Lin, L.; Chen, J.; Tian, H.*; Chen, X.*, Ultrasensitive pH triggered charge/size dual-rebound gene delivery system. Nano Letters 2016, 16 (11), 6823-6831.